Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
نویسندگان
چکیده
منابع مشابه
Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides
Circular nucleic acids have been utilized for versatile applications by taking advantage of the unique characteristic of their circular structure. In our previous study, we found that the chemically-cyclized ODN (cyODN) with double-tailed parts formed a pseudorotaxane structure with the target via the slippage process. We now report the investigation of the slippage properties and the mechanism...
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چکیده ندارد.
Complex formation between oligonucleotides and polymers.
Both deoxyribonucleic and ribonucleic acids appear to possess a secondary structure, by virtue of the fact that the purine and pyrimidine bases can undergo hydrogen bonding with each other. In the case of DNA, this secondary structure takes the form of a long, highly ordered helix composed of two strands held to each other by hydrogen bonds between the bases (l-3). The secondary structure of RN...
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A study of the characteristics of the guanine-cytosine bond is important to the understanding of its contributions to the secondary structure of nucleic acids. However, such a study is very difficult to carry out with synthetic homopolymers because of the occurrence of stable self-bonded guanine structures (1). It is almost impossible to obtain polyriboguanylic acid (poly Gl) in a single-strand...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2018
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gky744